Ornithine Decarboxylase Antizyme 1 (OAZ1) (Middle Region) Peptide
OAZ1
Reactivité: Souris
Hôte: Synthetic
BP, WB
N° du produit ABIN5511408
Aperçu rapide pour Ornithine Decarboxylase Antizyme 1 (OAZ1) (Middle Region) Peptide (ABIN5511408)
Antigène
OAZ1
(Ornithine Decarboxylase Antizyme 1 (OAZ1))
Origine
Souris
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
-
-
Protein Region
- Middle Region
-
Séquence
- PHPPLKIPGG RGNSQRDHSL SASILYSDER LNVTEEPTSN DKTRVLSIQS
-
Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-Oaz1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
-
-
-
-
Indications d'application
- Optimal working dilution should be determined by the investigator.
-
Restrictions
- For Research Use only
-
-
-
Format
- Lyophilized
-
Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
-
Stock
- -20 °C
-
Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
-
-
- OAZ1 (Ornithine Decarboxylase Antizyme 1 (OAZ1))
-
Sujet
-
The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis, thus, completing the auto-regulatory circuit. This gene encodes antizyme 1, the first member of the antizyme family, that has broad tissue distribution, and negatively regulates intracellular polyamine levels by binding to and targeting ODC for degradation, as well as inhibiting polyamine uptake. Antizyme 1 mRNA contains two potential in-frame AUGs, and studies in rat suggest that alternative use of the two translation initiation sites results in N-terminally distinct protein isoforms with different subcellular localization. Alternatively spliced transcript variants have also been noted for this gene.
Alias Symbols: AZ1, Oaz, AZ-1, ODC-Az, Antizyme
Protein Size: 227 -
ID gène
- 18245
-
NCBI Accession
- NM_008753, NP_032779
-
UniProt
- P54369
Antigène
-
Vous êtes ici:
